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Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring

19 Feb 2018

Abstract excerpt

The association between Zika virus (ZIKV) infection and congenital malformations such as microcephaly in infants is a public health emergency. Although various in vivo and in vitro models are used for ZIKV research, few animal models are available for resolving the effects of maternal ZIKV infection on neonatal development. Here, we established an immunocompetent mouse model via intrauterine inoculation. Our...

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PMID: 29476066
DOI: 10.1038/s41598-018-21894-w

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