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Article

Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits

10 Jun 2016

Abstract excerpt

Prader-Willi syndrome (PWS) is a genetic disorder characterized by a variety of physiological and behavioral dysregulations, including hyperphagia, a condition that can lead to life-threatening obesity. Feeding behavior is a highly complex process with multiple feedback loops that involve both peripheral and central systems. The arcuate nucleus of the hypothalamus (ARH) is critical for the regulation of...

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PMID: 27288456
DOI: 10.1093/hmg/ddw169

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Related research

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Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuitsPMID 27288456Read ↗

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Comparative Transcriptomic Analyses of Developing Melanocortin Neurons Reveal New Regulators for the Anorexigenic Neuron IdentitySemantic proximity Read ↗

Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.Semantic proximity Read ↗

<i>Magel2</i> in hypothalamic POMC neurons influences the impact of stress on anxiety-like behavior and spatial learning associated with a food reward in male miceSemantic proximity Read ↗

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