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Article

Targeted Mutational Analysis of Cortisol-Producing Adenomas.

The Journal of clinical endocrinology and metabolism - 18 Jan 2022

Rege Juilee, Hoxie Jessie, Liu Chia-Jen, Cash Morgan N, Luther James M, Gellert Lan, Turcu Adina F, Else Tobias, Giordano Thomas J, Udager Aaron M, Rainey William E, Nanba Kazutaka

Abstract excerpt

CONTEXT: Somatic gene mutations have been identified in only about half of cortisol-producing adenomas (CPAs). Affected genes include PRKACA, GNAS, PRKAR1A, and CTNNB1. OBJECTIVE: This work aims to expand our understanding of the prevalence of somatic mutations in CPAs from patients with overt Cushing syndrome (OCS) and "subclinical" mild autonomous cortisol excess (MACE), with an immunohistochemistry...

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Source

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Identifiers

PMID: 34534321
DOI: 10.1210/clinem/dgab682
PMCID: PMC8764218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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