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Article

PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas

7 Jun 2016

Abstract excerpt

CONTEXT: Somatic mutations have been found causative for endocrine autonomy in aldosterone-producing adenomas (APAs). Whereas mutations of PRKACA (catalytic subunit of protein kinase A) have been identified in cortisol-producing adenomas, the presence of PRKACA variants in APAs is unknown, especially in those that display cosecretion of cortisol. OBJECTIVE: The objective of the study was to investigate PRKACA...

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PMID: 27270477
DOI: 10.1210/jc.2016-1700

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