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Article

KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas.

Endocrine journal - 1 Jan 2012

Yamada Masanobu, Nakajima Yasuyo, Taguchi Ryo, Okamura Takashi, Ishii Sumiyasu, Tomaru Takuya, Ozawa Atsushi, Shibusawa Nobuyuki, Yoshino Satoshi, Toki Akiko, Ishida Emi, Hashimoto Koshi, Satoh Tetsurou, Mori Masatomo

Abstract excerpt

Adrenal aldosterone-producing adenomas (APA) are rarely associated with the clear co-secretion of cortisol. Somatic mutations of the potassium channel KCNJ5 gene, with the hotspots G151R and L168R, have been recently identified in patients with APA. However, whether APAs that secrete cortisol have these mutations remains unclear. We examined three patients with APAs showing clear autonomous secretion of cortisol...

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Share to Adrenal Cortex Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22863749
DOI: 10.1507/endocrj.ej12-0247

Genes

KCNJ5
DST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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