Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The essential and downstream common proteins of amyotrophic lateral sclerosis: A protein-protein interaction network analysis.

PloS one - 1 Jan 2017

Mao Yimin, Kuo Su-Wei, Chen Le, Heckman C J, Jiang M C

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a devastative neurodegenerative disease characterized by selective loss of motoneurons. While several breakthroughs have been made in identifying ALS genetic defects, the detailed molecular mechanisms are still unclear. These genetic defects involve in numerous biological processes, which converge to a common destiny: motoneuron degeneration. In addition, the common comorbid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Databases, Factual

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frontotemporal Dementia

Share to Heterogeneous Nuclear Ribonucleoprotein A1

Share to Heterogeneous-Nuclear Ribonucleoprotein Group A-B

Share to Protein Interaction Maps

Share to RNA-Binding Protein FUS

Share to Valosin Containing Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28282387
DOI: 10.1371/journal.pone.0172246
PMCID: PMC5345759

Genes

FUS
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The essential and downstream common proteins of amyotrophic lateral sclerosis: A protein-protein interaction network analysis.PMID 28282387Read ↗

A molecular view of amyotrophic lateral sclerosis through the lens of interaction network modules.Semantic proximity Read ↗

A Molecular View of Amyotrophic Lateral Sclerosis Through the Lens of Interaction Network ModulesSemantic proximity Read ↗

Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degenerations: Similarities in Genetic BackgroundSemantic proximity Read ↗

Amyotrophic lateral sclerosis: an update on recent genetic insights.Semantic proximity Read ↗

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathwaysSemantic proximity Read ↗

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal DementiaSemantic proximity Read ↗

Tale of two diseases: amyotrophic lateral sclerosis and frontotemporal dementia.Semantic proximity Read ↗

Identification of potentially functional modules and diagnostic genes related to amyotrophic lateral sclerosis based on the WGCNA and LASSO algorithmsSemantic proximity Read ↗

New ALS-Related Genes Expand the Spectrum Paradigm of Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Key Molecules and Pathways Underlying Sporadic Amyotrophic Lateral Sclerosis: Integrated Analysis on Gene Expression Profiles of Motor NeuronsSemantic proximity Read ↗

Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)Semantic proximity Read ↗

Sporadic Amyotrophic Lateral Sclerosis Skeletal Muscle Transcriptome Analysis: A Comprehensive Examination of Differentially Expressed GenesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.