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Article

Making connections: pathology and genetics link amyotrophic lateral sclerosis with frontotemporal lobe dementia.

Journal of molecular neuroscience : MN - 1 Nov 2011

Fecto Faisal, Siddique Teepu

Abstract excerpt

Over the last couple of decades, there has been a growing body of clinical, genetic, and histopathological evidence that similar pathological processes underlie amyotrophic lateral sclerosis (ALS) and some types of frontotemporal lobe dementia (FTD). Even though there is great diversity in the genetic causes of these disorders, there is a high degree of overlap in their histopathology. Genes linked to rare cases...

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Source

Identifiers

PMID: 21901496
DOI: 10.1007/s12031-011-9637-9

Genes

FUS
OPTN
TARDBP
UBQLN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Genetic architecture of amyotrophic lateral sclerosis and frontotemporal dementia : Overlap and differences].Semantic proximity Read ↗

Defining the genetic connection linking amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD).Semantic proximity Read ↗

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