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Article

Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.

The Journal of biological chemistry - 28 Apr 2006

Jain Abhinav K, Jaiswal Anil K

Abstract excerpt

Nuclear factor Nrf 2, under normal conditions, is retained in the cytosol by INrf 2. Antioxidants and oxidants antagonize this interaction, resulting in the release of Nrf 2. Nrf 2 translocates to the nucleus binds to ARE and activates a battery of chemopreventive genes. Once this is achieved, Nrf 2 is exported out of the nucleus, binds with INrf 2, and degrades. Nrf 2 contains well defined signals that control...

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PMID: 16513647
DOI: 10.1074/jbc.M511198200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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