A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses

Abstract excerpt

The phosphorylation of the subunit alpha of eukaryotic translation initiation factor 2 (eIF2alpha), a critical regulatory event in controlling protein translation, has recently been found to mediate the induction of autophagy. However, the mediators of autophagy downstream of eIF2alpha remain unknown. Here, we provide evidence that eIF2alpha phosphorylation is required for phosphorylation of eukaryotic elongation...

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