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Article

Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2.

The Journal of biological chemistry - 4 Apr 2008

Theodore Melanie, Kawai Yumiko, Yang Jianqi, Kleshchenko Yuliya, Reddy Sekhar P, Villalta Fernando, Arinze Ifeanyi J

Abstract excerpt

Nuclear factor erythroid 2-related factor 2 (Nrf2) mediates the transcriptional response of cells to oxidative stress and is translocated into the nucleus following, or concomitant with, its activation by electrophiles or reactive oxygen species. The mechanism of its translocation into the nucleus is not entirely elucidated. Here we have identified two novel nuclear localization signal (NLS) motifs in murine...

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Identifiers

PMID: 18238777
DOI: 10.1074/jbc.M709040200
PMCID: PMC2276363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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