Article
Rare-Variant Kernel Machine Test for Longitudinal Data from Population and Family Samples.
Human heredity - 1 Jan 2015
Yan Qi, Weeks Daniel E, Tiwari Hemant K, Yi Nengjun, Zhang Kui, Gao Guimin, Lin Wan-Yu, Lou Xiang-Yang, Chen Wei, Liu Nianjun
Abstract excerpt
OBJECTIVE: The kernel machine (KM) test reportedly performs well in the set-based association test of rare variants. Many studies have been conducted to measure phenotypes at multiple time points, but the standard KM methodology has only been available for phenotypes at a single time point. In addition, family-based designs have been widely used in genetic association studies; therefore, the data analysis method...
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