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Article

A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model.

Human heredity - 1 Jan 2015

Yan Qi, Tiwari Hemant K, Yi Nengjun, Gao Guimin, Zhang Kui, Lin Wan-Yu, Lou Xiang-Yang, Cui Xiangqin, Liu Nianjun

Abstract excerpt

OBJECTIVE: The existing methods for identifying multiple rare variants underlying complex diseases in family samples are underpowered. Therefore, we aim to develop a new set-based method for an association study of dichotomous traits in family samples. METHODS: We introduce a framework for testing the association of genetic variants with diseases in family samples based on a generalized linear mixed model. Our...

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PMID: 25791389
DOI: 10.1159/000375409
PMCID: PMC4825859

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