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Article

Rare variant association test in family-based sequencing studies.

Briefings in bioinformatics - 1 Nov 2017

Wang Xuefeng, Zhang Zhenyu, Morris Nathan, Cai Tianxi, Lee Seunggeun, Wang Chaolong, Yu Timothy W, Walsh Christopher A, Lin Xihong

Abstract excerpt

The objective of this article is to introduce valid and robust methods for the analysis of rare variants for family-based exome chips, whole-exome sequencing or whole-genome sequencing data. Family-based designs provide unique opportunities to detect genetic variants that complement studies of unrelated individuals. Currently, limited methods and software tools have been developed to assist family-based...

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Identifiers

PMID: 27677958
DOI: 10.1093/bib/bbw083
PMCID: PMC5862290

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