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Article

Rare-variant association tests in longitudinal studies, with an application to the Multi-Ethnic Study of Atherosclerosis (MESA).

Genetic epidemiology - 1 Dec 2017

He Zihuai, Lee Seunggeun, Zhang Min, Smith Jennifer A, Guo Xiuqing, Palmas Walter, Kardia Sharon L R, Ionita-Laza Iuliana, Mukherjee Bhramar

Abstract excerpt

Over the past few years, an increasing number of studies have identified rare variants that contribute to trait heritability. Due to the extreme rarity of some individual variants, gene-based association tests have been proposed to aggregate the genetic variants within a gene, pathway, or specific genomic region as opposed to a one-at-a-time single variant analysis. In addition, in longitudinal studies,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29076270
DOI: 10.1002/gepi.22081
PMCID: PMC5696115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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