Article
A Fast Multiple-Kernel Method With Applications to Detect Gene-Environment Interaction.
Genetic epidemiology - 1 Sept 2015
Marceau Rachel, Lu Wenbin, Holloway Shannon, Sale Michèle M, Worrall Bradford B, Williams Stephen R, Hsu Fang-Chi, Tzeng Jung-Ying
Abstract excerpt
Kernel machine (KM) models are a powerful tool for exploring associations between sets of genetic variants and complex traits. Although most KM methods use a single kernel function to assess the marginal effect of a variable set, KM analyses involving multiple kernels have become increasingly popular. Multikernel analysis allows researchers to study more complex problems, such as assessing gene-gene or...
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