Article
Cigarette smoke induced genotoxicity and respiratory tract pathology: evidence to support reduced exposure time and animal numbers in tobacco product testing.
Inhalation toxicology - 1 Jun 2016
Dalrymple Annette, Ordoñez Patricia, Thorne David, Walker David, Camacho Oscar M, Büttner Ansgar, Dillon Debbie, Meredith Clive
Abstract excerpt
Many laboratories are working to develop in vitro models that will replace in vivo tests, but occasionally there remains a regulatory expectation of some in vivo testing. Historically, cigarettes have been tested in vivo for 90 days. Recently, methods to reduce and refine animal use have been explored. This study investigated the potential of reducing animal cigarette smoke (CS) exposure to 3 or 6 weeks, and the...
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