Article
A further review of inhalation studies with cigarette smoke and lung cancer in experimental animals, including transgenic mice.
Inhalation toxicology - 1 Oct 2010
Coggins C R E
Abstract excerpt
CONTEXT: The lack of an effective animal model for pulmonary carcinogenesis in smokers is a continuing problem for researchers trying to design Potentially Reduced Risk Products for those smokers who are either unwilling or unable to quit smoking. The major failing of inhalation assays with cigarette smoke in laboratory animals is that these assays produce only small percentages of animals with pulmonary tumors...
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