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Article

Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer.

PloS one - 1 Jan 2013

Sung Shian-Ying, Liao Chia-Hui, Wu Hsun-Pai, Hsiao Wan-Chi, Wu I-Hui, Jinpu, Yu, Lin Sue-Hwa, Hsieh Chia-Ling

Abstract excerpt

Bone marrow-derived mesenchymal stem cells (MSCs) are able to migrate to tumors, where they promote tumorigenesis and cancer metastasis. However, the molecular phenotype of the recruited MSCs at the tumor microenvironment and the genetic programs underlying their role in cancer progression remains largely unknown. By using a three-dimensional rotary wall vessel coculture system in which human MSCs were grown...

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Identifiers

PMID: 23977098
DOI: 10.1371/journal.pone.0071637
PMCID: PMC3747243

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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