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Article

APOE Locus-Associated Mitochondrial Function and Its Implication in Alzheimer's Disease and Aging.

International journal of molecular sciences - 21 Jun 2023

Lee Eun-Gyung, Leong Lesley, Chen Sunny, Tulloch Jessica, Yu Chang-En

Abstract excerpt

The Apolipoprotein E (APOE) locus has garnered significant clinical interest because of its association with Alzheimer's disease (AD) and longevity. This genetic association appears across multiple genes in the APOE locus. Despite the apparent differences between AD and longevity, both conditions share a commonality of aging-related changes in mitochondrial function. This commonality is likely due to accumulative...

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Identifiers

PMID: 37445616
DOI: 10.3390/ijms241310440
PMCID: PMC10341489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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