Article
East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome.
Circulation - 12 May 2015
Mizuno Yuji, Harada Eisaku, Morita Sumio, Kinoshita Kenji, Hayashida Mariko, Shono Makoto, Morikawa Yoshinobu, Murohara Toyoaki, Nakayama Masafumi, Yoshimura Michihiro, Yasue Hirofumi
Abstract excerpt
BACKGROUND: Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is...
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