Article
Variant Aldehyde Dehydrogenase 2 (ALDH2*2) in East Asians Interactively Exacerbates Tobacco Smoking Risk for Coronary Spasm - Possible Role of Reactive Aldehydes.
Circulation journal : official journal of the Japanese Circulation Society - 22 Dec 2016
Mizuno Yuji, Hokimoto Seiji, Harada Eisaku, Kinoshita Kenji, Yoshimura Michihiro, Yasue Hirofumi
Abstract excerpt
BACKGROUND: Coronary spastic angina (CSA) is common among East Asians and tobacco smoking (TS) is an established risk factor for CSA. Aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing reactive toxic aldehydes and a deficient variant ALDH2 genotype (ALDH2*2) is prevalent among East Asians. We examined the interaction between TS andALDH2*2as a risk factor for CSA to better understand the disease...
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