Article
Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines.
PloS one - 1 Jan 2011
Chang Han, Jackson Donald G, Kayne Paul S, Ross-Macdonald Petra B, Ryseck Rolf-Peter, Siemers Nathan O
Abstract excerpt
It is well established that genomic alterations play an essential role in oncogenesis, disease progression, and response of tumors to therapeutic intervention. The advances of next-generation sequencing technologies (NGS) provide unprecedented capabilities to scan genomes for changes such as mutations, deletions, and alterations of chromosomal copy number. However, the cost of full-genome sequencing still...
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