Article
Comprehensive analyses of somatic TP53 mutation in tumors with variable mutant allele frequency.
Scientific data - 5 Sept 2017
Cole Alexander J, Zhu Ying, Dwight Trisha, Yu Bing, Dickson Kristie-Ann, Gard Gregory B, Maidens Jayne, Valmadre Susan, Gill Anthony J, Clifton-Bligh Roderick, Marsh Deborah J
Abstract excerpt
Somatic mutation of the tumor suppressor gene TP53 is reported in at least 50% of human malignancies. Most high-grade serous ovarian cancers (HGSC) have a mutant TP53 allele. Accurate detection of these mutants in heterogeneous tumor tissue is paramount as therapies emerge to target mutant p53. We used a Fluidigm Access Array™ System with Massively Parallel Sequencing (MPS) to analyze DNA extracted from 76 serous...
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