Article
Characterization of TP53 mutations in Pap test DNA of women with and without serous ovarian carcinoma.
Gynecologic oncology - 1 Feb 2020
Krimmel-Morrison Jeffrey D, Ghezelayagh Talayeh S, Lian Shenyi, Zhang Yuezheng, Fredrickson Jeanne, Nachmanson Daniela, Baker Kathryn T, Radke Marc R, Hun Enna, Norquist Barbara M, Emond Mary J, Swisher Elizabeth M, Risques Rosa Ana
Abstract excerpt
OBJECTIVE: Pap tests hold promise as a molecular diagnostic for serous ovarian cancer, but previous studies reported limited sensitivity. Furthermore, the presence of somatic mutations in normal tissue is increasingly recognized as a challenge to the specificity of mutation-based cancer diagnostics. We applied an ultra-deep sequencing method with the goal of improving sensitivity and characterizing the landscape...
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