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Article

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary.

The Journal of pathology - 1 May 2010

Ahmed Ahmed Ashour, Etemadmoghadam Dariush, Temple Jillian, Lynch Andy G, Riad Mohamed, Sharma Raghwa, Stewart Colin, Fereday Sian, Caldas Carlos, Defazio Anna, Bowtell David, Brenton James D

Abstract excerpt

Numerous studies have tested the association between TP53 mutations in ovarian cancer and prognosis but these have been consistently confounded by limitations in study design, methodology, and/or heterogeneity in the sample cohort. High-grade serous (HGS) carcinoma is the most clinically important histological subtype of ovarian cancer. As these tumours may arise from the ovary, Fallopian tube or peritoneum, they...

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Share to Antineoplastic Combined Chemotherapy Protocols
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20229506
DOI: 10.1002/path.2696
PMCID: PMC3262968

Genes

HGS
MDM2
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary.PMID 20229506Read ↗

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