Article
Type 1 Deiodinase Regulates ApoA-I Gene Expression and ApoA-I Synthesis Independent of Thyroid Hormone Signaling.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2016
Liu Jing, Hernandez-Ono Antonio, Graham Mark J, Galton Valerie Anne, Ginsberg Henry N
Abstract excerpt
OBJECTIVE: Plasma levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) are reduced in individuals with defective insulin signaling. Initial studies using liver-specific insulin receptor (InsR) knockout mice identified reduced expression of type 1 deiodinase (Dio1) as a potentially novel link between defective hepatic insulin signaling and reduced expression of the ApoA-I gene....
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