Article

Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression

2021-05-14

Abstract excerpt

<h4>Objective</h4> Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum ranging from hepatosteatosis to progressive non-alcoholic steatohepatitis that can lead to cirrhosis. Humans with low levels of the prohormone thyroxine (T 4 ) have a higher incidence of NAFLD and thyroid hormone treatment is very promising in all patients with NAFLD. Deiodinase 1 (Dio1) is a hepatic enzyme that converts T 4 to th...

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Literature Corpus work: 829758b0-757d-55fd-9d42-feee7b0990d1
DOI: 10.1101/2021.05.13.443791

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