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Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.

Toxicology - 4 May 2015

Kijima Aki, Ishii Yuji, Takasu Shinji, Matsushita Kohei, Kuroda Ken, Hibi Daisuke, Suzuki Yuta, Nohmi Takehiko, Umemura Takashi

Abstract excerpt

Nitrofurans are antimicrobial compounds containing a nitro group at the 5-position of the furan ring and an amine or hydrazide side chain derivative. One member of the nitrofurans, nitrofurantoin (NFT), is a renal carcinogen in male rats despite its still controversial genotoxicity. We investigated chemical structure-related modes of action of NFT, and reporter gene mutation assays for NFT and its constituent...

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PMID: 25772432
DOI: 10.1016/j.tox.2015.03.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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