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Article

The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching

26 May 2008

Abstract excerpt

Blood vessel formation requires the integrated regulation of endothelial cell proliferation and branching morphogenesis, but how this coordinated regulation is achieved is not well understood. Flt-1 (vascular endothelial growth factor [VEGF] receptor 1) is a high affinity VEGF-A receptor whose loss leads to vessel overgrowth and dysmorphogenesis. We examined the ability of Flt-1 isoform transgenes to rescue the...

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PMID: 18504303
DOI: 10.1083/jcb.200709114

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