Article
Local guidance of emerging vessel sprouts requires soluble Flt-1.
Developmental cell - 1 Sept 2009
Chappell John C, Taylor Sarah M, Ferrara Napoleone, Bautch Victoria L
Abstract excerpt
Blood vessel networks form via sprouting of endothelial cells from parent vessels. Extrinsic cues guide sprouts after they leave the initiation site, but these cues are likely insufficient to regulate initial outward movement, and many embryonic vessel networks form in the absence of a strong extrinsic gradient. We hypothesized that nascent sprouts are guided by spatial cues produced along their own vessels, and...
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