Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity.

European journal of drug metabolism and pharmacokinetics - 1 Mar 2013

Rahmioglu Nilufer, Heaton James, Clement Gail, Gill Raj, Surdulescu Gabriela, Zlobecka Karolina, Hodgkiss Dylan, Smith Norman W, Ahmadi Kourosh R

Abstract excerpt

Atypical cytochrome P450 3A4 (CYP3A4) enzyme activity-induced and inhibited-is thought to be the driver of numerous poor or adverse therapeutic responses to up to 50 % of all commonly prescribed drugs. We carried out a genome-wide association study to identify common genetic variants associated w...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Induction

Share to Hydroxylation

Share to Quinidine

Share to Quinine

Share to Substrate Specificity

Source

Identifiers

PMID: 22945461
DOI: 10.1007/s13318-012-0103-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22945461-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity.PMID 22945461Read ↗

Why We Need to Take a Closer Look at Genetic Contributions to CYP3A ActivitySemantic proximity Read ↗

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Semantic proximity Read ↗

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome datasetSemantic proximity Read ↗

Advancing CYP2D6 Pharmacogenetics through a Pharmacoequity Lens.Semantic proximity Read ↗

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment.Semantic proximity Read ↗

The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.Semantic proximity Read ↗

Genetics of the Variable Expression of CYP3A in HumansSemantic proximity Read ↗

Advances in human cytochrome p450 and personalized medicine.Semantic proximity Read ↗

Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes.Semantic proximity Read ↗

Cytochrome P450 in Pharmacogenetics: An Update.Semantic proximity Read ↗

Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy.Semantic proximity Read ↗

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.