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Article

CAV1-A Susceptibility Gene for Atrial Fibrillation: The Impact of Coding and Noncoding Variants.

Journal of the American Heart Association - 3 Feb 2026

Rädecke Kristin, Rheinert David, Löwen Annette, Wiedmann Felix, Diebold Sabrina, Diofano Federica, Weiß Birgit, Röth Ralph, Schmitteckert Stefanie, Clauss Sebastian, Kääb Stefan, Just Steffen, Schmidt Constanze, Rappold Gudrun A, Hoffmann Sandra

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with a strong genetic predisposition. Genome-wide association studies have highlighted CAV1 (caveolin 1), a caveolar protein involved in various signaling pathways, as a candidate for cardiac conduction disorders. METHODS: We explored the role of CAV1 in AF in various models to dissect possible disease mechanisms. First, CAV1...

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Animals, Genetically Modified
Atrial Fibrillation
Caveolin 1
Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Zebrafish Proteins

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Open in PubMed Open full text

Identifiers

PMID: 41568559
DOI: 10.1161/JAHA.125.041586
PMCID: PMC13055488

Genes

CAV1
SHOX2
EOMES
MAX
TEAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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