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Article

Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation.

Journal of medical genetics - 1 Jan 2015

Tsai Chia-Ti, Hsieh Chia-Shan, Chang Sheng-Nan, Chuang Eric Y, Juang Jyh-Ming Jimmy, Lin Lian-Yu, Lai Ling-Ping, Hwang Juey-Jen, Chiang Fu-Tien, Lin Jiunn-Lee

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Genome-wide association studies (GWAS) have identified common variants in nine genomic regions associated with AF (KCNN3, PRRX1, PITX2, WNT8A, CAV1, C9orf3, SYNE2, HCN4 and ZFHX3 genes); however, the genetic variability of these risk variants does not explain the entire genetic susceptibility to AF. Rare variants missed by GWAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25391453
DOI: 10.1136/jmedgenet-2014-102618

Genes

PITX2
ZFHX3
KCNN3
CAV1
HCN4
PRRX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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