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Article

ABCB1 C3435T gene polymorphism as a potential biomarker of clinical outcomes in HER2-positive breast cancer patients.

Pharmacological research - 1 Jun 2016

Madrid-Paredes Adela, Cañadas-Garre Marisa, Sánchez-Pozo Antonio, Segura-Pérez Ana María, Chamorro-Santos Clara, Vergara-Alcaide Esther, Castillo-Portellano Lucía, Calleja-Hernández Miguel Ángel

Abstract excerpt

HER2-positive breast cancer patients treated with trastuzumab schemes have good initial clinical outcomes. Despite this beneficial effect, many patients experiment resistance to these drugs. Several gene polymorphisms in ABCB1, HER2, and CCND1 have been proposed as potential predictors of clinical outcomes of trastuzumab schemes. The aim of this study was to evaluate the association between 4 gene polymorphisms...

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Share to Antineoplastic Agents, Immunological
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, ErbB-2

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Source

Identifiers

PMID: 27137881
DOI: 10.1016/j.phrs.2016.04.016

Genes

ABCB1
CCND1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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