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Article

ABCB1 gene polymorphisms and response to chemotherapy in breast cancer patients: A meta-analysis.

Surgical oncology - 1 Dec 2017

Madrid-Paredes Adela, Cañadas-Garre Marisa, Sánchez-Pozo Antonio, Expósito-Ruiz Manuela, Calleja-Hernández Miguel Ángel

Abstract excerpt

The ABCB1 gene encodes the P-glycoprotein, an efflux pump for some antineoplastic agents which acts as a resistance mechanism to chemotherapy. Three SNPs (C3435T, C1236T and G2677T/A), are the most widely studied in ABCB1. The inconsistent conclusions about the association of these polymorphisms and the response to chemotherapy in breast cancer (BC) patients prompted us to conduct a meta-analysis. A total of nine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29113667
DOI: 10.1016/j.suronc.2017.09.004

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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