Article
The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder.
Neurobiology of aging - 1 Jul 2016
Gan-Or Ziv, Mohsin Noreen, Girard Simon L, Montplaisir Jacques Y, Ambalavanan Amirthagowri, Strong Stephanie, Mallett Victoria, Laurent Sandra B, Bourassa Cynthia V, Boivin Michel, Langlois Melanie, Arnulf Isabelle, Högl Birgit, Frauscher Birgit, Monaca Christelle, Desautels Alex, Gagnon Jean-François, Postuma Ronald B, Dion Patrick A, Dauvilliers Yves, Dupre Nicolas, Alcalay Roy N, Rouleau Guy A
Abstract excerpt
The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency > 0.01. None of the common...
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