Article
MC1R gene variants and sporadic malignant melanoma susceptibility in the Canary Islands population.
Archives of dermatological research - 1 Jan 2014
Córdoba-Lanús Elizabeth, Hernández-Jiménez José G, Medina-Coello Chaxiraxi, Espinoza-Jiménez Adriana, González Ana, Rodríguez-Pérez María-Del-Cristo, Carretero-Hernández Gregorio, Almeida Pablo, Suárez-Hernández José, Perera-Molinero Antonio, Fernández-de-Misa Ricardo
Abstract excerpt
Several MC1R variants are associated with increased risk of malignant melanoma (MM) in a variety of populations. We aim to examine the influence of the MC1R variants (RHC: D84E, R151C, R160W; NRHC: V60L, R163Q and the synonymous polymorphism T314T) on the MM risk in a population from the Canary Islands. Overall, 1,046 Caucasian individuals were included in the study. A thousand of them were genotyped for MC1R...
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