Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

27 Apr 2016

Abstract excerpt

Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in Nf1-deficient mice is independent of Nf1's role in down-modulating RAS-MAPK signaling. We demonstrate in zebrafish that nf1 loss leads to aberrant activation of RAS signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroblastoma Research and Treatments
Share to Neurofibromatosis and Schwannoma Cases
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27130733
DOI: 10.7554/elife.14713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domainPMID 27130733Read ↗

Disruption of Cooperation Between Ras and MycN in Human Neuroblastoma Cells Promotes Growth ArrestSemantic proximity Read ↗

Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistanceSemantic proximity Read ↗

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.Semantic proximity Read ↗

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.Semantic proximity Read ↗

Neuroblastoma and Its Zebrafish Model.Semantic proximity Read ↗

Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumorsSemantic proximity Read ↗

The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesisSemantic proximity Read ↗

Cannabinol Inhibits Cellular Proliferation, Invasion, and Angiogenesis of Neuroblastoma via Novel miR-34a/tRiMetF31/PFKFB3 AxisSemantic proximity Read ↗

Expansion of a neural crest gene signature following ectopic MYCN expression in sympathoadrenal lineage cells in vivoSemantic proximity Read ↗

Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition.Semantic proximity Read ↗

Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathwaysSemantic proximity Read ↗

Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.