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Article

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.

Cell reports - 21 Mar 2017

Zhang Xiaoling, Dong Zhiwei, Zhang Cheng, Ung Choong Yong, He Shuning, Tao Ting, Oliveira Andre M, Meves Alexander, Ji Baoan, Look A Thomas, Li Hu, Neel Benjamin G, Zhu Shizhen

Abstract excerpt

Growing evidence suggests a major role for Src-homology-2-domain-containing phosphatase 2 (SHP2/PTPN11) in MYCN-driven high-risk neuroblastoma, although biologic confirmation and a plausible mechanism for this contribution are lacking. Using a zebrafish model of MYCN-overexpressing neuroblastoma, we demonstrate that mutant ptpn11 expression in the adrenal gland analog of MYCN transgenic fish promotes the...

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Source

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Identifiers

PMID: 28329685
DOI: 10.1016/j.celrep.2017.02.065
PMCID: PMC5393048

Genes

MYCN
GAB2
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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