Article
Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.
Cell reports - 21 Mar 2017
Zhang Xiaoling, Dong Zhiwei, Zhang Cheng, Ung Choong Yong, He Shuning, Tao Ting, Oliveira Andre M, Meves Alexander, Ji Baoan, Look A Thomas, Li Hu, Neel Benjamin G, Zhu Shizhen
Abstract excerpt
Growing evidence suggests a major role for Src-homology-2-domain-containing phosphatase 2 (SHP2/PTPN11) in MYCN-driven high-risk neuroblastoma, although biologic confirmation and a plausible mechanism for this contribution are lacking. Using a zebrafish model of MYCN-overexpressing neuroblastoma, we demonstrate that mutant ptpn11 expression in the adrenal gland analog of MYCN transgenic fish promotes the...
Topics
- Animals
- Animals, Genetically Modified
- Apoptosis
- Carbazoles
- Carcinogenesis
- Carrier Proteins
- Cell Proliferation
- Gene Amplification
- Gene Expression Profiling
- Humans
- MAP Kinase Signaling System
- Mutation
- N-Myc Proto-Oncogene Protein