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Article

Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.

Genes & development - 1 Dec 2006

Walker James A, Tchoudakova Anna V, McKenney Peter T, Brill Suzanne, Wu Dongyun, Cowley Glenn S, Hariharan Iswar K, Bernards André

Abstract excerpt

Neurofibromatosis type 1 (NF1) is among the most common genetic disorders of humans and is caused by loss of neurofibromin, a large and highly conserved protein whose only known function is to serve as a GTPase-Activating Protein (GAP) for Ras. However, most Drosophila NF1 mutant phenotypes, including an overall growth deficiency, are not readily modified by manipulating Ras signaling strength, but are rescued by...

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PMID: 17114577
DOI: 10.1101/gad.1466806
PMCID: PMC1686607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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