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Article

Disruption of Cooperation Between Ras and MycN in Human Neuroblastoma Cells Promotes Growth Arrest

15 Jun 2005

Abstract excerpt

PURPOSE: Our aim was to examine whether active Ras and MycN cooperation contributes to the malignant phenotype of human neuroblastoma with amplified MycN gene, an aggressive incurable tumor. EXPERIMENTAL DESIGN: Human neuroblastoma LAN-1 cells, in which the MycN gene is amplified, were used to examine the impact of the Ras inhibitor farnesylthiosalicylic acid on cell growth, on the levels Ras and MycN proteins,...

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PMID: 15958613
DOI: 10.1158/1078-0432.ccr-04-2071

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of Cooperation Between Ras and MycN in Human Neuroblastoma Cells Promotes Growth ArrestPMID 15958613Read ↗

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