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Article

Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition.

Development (Cambridge, England) - 1 Nov 2011

Reiff Tobias, Huber Leslie, Kramer Marco, Delattre Olivier, Janoueix-Lerosey Isabelle, Rohrer Hermann

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and arises from cells of the developing sympathoadrenergic lineage. Activating mutations in the gene encoding the ALK tyrosine kinase receptor predispose for NB. Here, we focus on the normal function of Alk signaling in the control of sympathetic neuron proliferation, as well as on the effects of mutant ALK. Forced expression of wild-type...

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Source

Identifiers

PMID: 21989914
DOI: 10.1242/dev.072157

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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