Article
The pH-dependent Client Release from the Collagen-specific Chaperone HSP47 Is Triggered by a Tandem Histidine Pair.
The Journal of biological chemistry - 10 Jun 2016
Oecal Sinan, Socher Eileen, Uthoff Matthias, Ernst Corvin, Zaucke Frank, Sticht Heinrich, Baumann Ulrich, Gebauer Jan M
Abstract excerpt
Heat shock protein 47 (HSP47) is an endoplasmic reticulum (ER)-resident collagen-specific chaperone and essential for proper formation of the characteristic collagen triple helix. It preferentially binds to the folded conformation of its clients and accompanies them from the ER to the Golgi compartment, where it releases them and is recycled back to the ER. Unlike other chaperones, the binding and release cycles...
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