Article

Mutational Hotspots and Protein Interactome Analyses of Collagen-Specific Chaperone—HSP47

2018-11-12

Abstract excerpt

Heat shock protein 47kDa (HSP47) serves as a client-specific chaperone, essential for collagen biosynthesis and its folding and structural assembly. To date, there is no comprehensive study on mutational hotspots and protein network for human HSP47. Using five different human mutational databases, we deduced a comprehensive list of human HSP47 mutations and we found 24 67, 50, 43 and 2 deleterious mutations from t...

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Literature Corpus work: af83483a-bdf5-5676-8fc3-a67fcc15267b
DOI: 10.20944/preprints201811.0280.v1

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