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Article

Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline.

Age (Dordrecht, Netherlands) - 1 Jun 2016

Curjuric Ivan, Imboden Medea, Bridevaux Pierre-Olivier, Gerbase Margaret W, Haun Margot, Keidel Dirk, Kumar Ashish, Pons Marco, Rochat Thierry, Schikowski Tamara, Schindler Christian, von Eckardstein Arnold, Kronenberg Florian, Probst-Hensch Nicole M

Abstract excerpt

Lung function is an independent predictor of mortality and serves as an aging marker in never smokers. The protein sirtuin-1 of gene SIRT1 has profound anti-inflammatory effects and regulates metabolic pathways. Its suggested longevity effects on lower organisms remain poorly studied in humans. In 1132 never smokers of the population-based SAPALDIA cohort, we investigated associations between single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27125385
DOI: 10.1007/s11357-016-9917-y
PMCID: PMC5005914

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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