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Article

Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China.

Environmental health : a global access science source - 14 Mar 2021

Yao Yao, Liu Linxin, Guo Guang, Zeng Yi, Ji John S

Abstract excerpt

BACKGROUND: The SIRT1 gene was associated with the lifespan in several organisms through inflammatory and oxidative stress pathways. Long-term air particulate matter (PM) is detrimental to health through the same pathways. METHODS: We used the Chinese Longitudinal Healthy Longevity Survey (CLHLS) to investigate whether there is a gene-environment (G × E) interaction of SIRT1 and air pollution on mortality in an...

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Identifiers

PMID: 33715628
DOI: 10.1186/s12940-021-00718-x
PMCID: PMC7958462

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