Article
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jul 2017
Razi Shajjia, Cogger Victoria C, Kennerson Marina, Benson Vicky L, McMahon Aisling C, Blyth Fiona M, Handelsman David J, Seibel Markus J, Hirani Vasant, Naganathan Vasikaran, Waite Louise, de Cabo Rafael, Cumming Robert G, Le Couteur David G
Abstract excerpt
The nutrient sensing protein, SIRT1 influences aging and nutritional interventions such as caloric restriction in animals, however, the role of SIRT1 in human aging remains unclear. Here, the role of SIRT1 single-nucleotide polymorphisms (SNPs) and serum-induced SIRT1 protein expression (a novel assay that detects circulating factors that influence SIRT1 expression in vitro) were studied in the Concord Health and...
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