Article
Association of SIRT1 gene variation with visceral obesity.
Human genetics - 1 Nov 2008
Peeters Armand V, Beckers Sigri, Verrijken An, Mertens Ilse, Roevens Peter, Peeters Pieter J, Van Hul Wim, Van Gaal Luc F
Abstract excerpt
The sirtuin SIRT1 is an important regulator of energy metabolism through its impact on glucose and lipid metabolism and therefore we tested the hypothesis that genetic variation in SIRT1 may have an effect on adiposity in a Belgian case/control association study. This study included 1,068 obese patients (BMI > or = 30 kg/m(2)) from the outpatient obesity clinic and 313 lean controls (BMI between 18.5 and 25...
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