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Article

SIRT1 genetic variation is related to BMI and risk of obesity.

Diabetes - 1 Dec 2009

Zillikens M Carola, van Meurs Joyce B J, Rivadeneira Fernando, Amin Najaf, Hofman Albert, Oostra Ben A, Sijbrands Eric J G, Witteman Jacqueline C M, Pols Huibert A P, van Duijn Cornelia M, Uitterlinden André G

Abstract excerpt

OBJECTIVE: SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity. RESEARCH DESIGN AND METHODS: In 6,251 elderly subjects from the prospective, population-based Rotterdam Study, three single nucleotide polymorphisms (SNPs) in the SIRT1 gene were studied in relation to BMI and risk of obesity (BMI > or =30 kg/m(2)) and prospectively with BMI change...

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Source

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Identifiers

PMID: 19741164
DOI: 10.2337/db09-0536
PMCID: PMC2780870

Genes

SIRT1
ERF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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