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Article

Definition of MYC genetic heteroclonality in diffuse large B-cell lymphoma with 8q24 rearrangement and its impact on protein expression.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2016

Valera Alexandra, Epistolio Samantha, Colomo Lluis, Riva Alice, Balagué Olga, Dlouhy Ivan, Tzankov Alexandar, Bühler Marco, Haralambieva Eugenia, Campo Elias, Soldini Davide, Mazzucchelli Luca, Martin Vittoria

Abstract excerpt

MYC rearrangement can be detected in a subgroup of diffuse large B-cell lymphoma characterized by unfavorable prognosis. In contrast to Burkitt lymphoma, the correlation between MYC rearrangement and MYC protein expression in diffuse large B-cell lymphoma is less clear, as approximately one-third of rearranged cases show negative or low expression by immunohistochemistry. To better understand whether specific...

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Topics

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Share to Chromosomes, Human, Pair 8
Share to Gene Rearrangement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, Large B-Cell, Diffuse

Share to Proto-Oncogene Proteins c-myc

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Source

Identifiers

PMID: 27125356
DOI: 10.1038/modpathol.2016.71

Genes

MYC
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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